Challenging Cases in Chronic Myeloid Leukemia (CML): Drs. Fadi Haddad & Gaby Hobbs

Welcome to the Oncology Brothers podcast! In this episode, we dived into the complexities of chronic myeloid leukemia (CML) through two challenging case studies. Joined by CML experts Dr. Fadi Haddad from MD Anderson Cancer Center and Dr. Gaby Hobbs from Massachusetts General Hospital, 

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we talked about:

• The initial workup for diagnosing CML, including the importance of CBC, bone marrow biopsy, and BCR-ABL testing.
• How to select the most optimal frontline treatment option amongst many available, considering factors like age, comorbidities, and the goal of treatment-free remission (TFR).
• The role of first-generation TKI, but also how newer TKIs assist in achieving deeper molecular remissions.
• Strategies for managing treatment breaks and monitoring patients in remission.
• The role of ponatinib as a pan-BCR:ABL1 inhibitor effective against all known resistance mutations, including T315I, and the optimized response-based dosing strategy to balance efficacy with safety.

Tune in for valuable insights on treatment strategies, patient management, and the latest advancements in CML care. Don't forget to like, subscribe, and share your challenging case scenarios for future discussions!

#ChronicMyeloidLeukemia, #CML, #TreatmentFreeRemission, #OncologyBrothers