Lung Cancer ASCO 2026 Highlights: LIBRETTO-432, CROWN Update, CHRYSALIS-2, HARMONi-6

Welcome back to the Oncology Brothers podcast! In this episode, we were joined by Dr. Isabel Preeshagul from Memorial Sloan-Kettering to discuss the latest advancements in lung cancer presented at ASCO 2026.

 

We dived into four key studies that could change clinical practice:

• LIBRETTO-432: exploring the promising event-free survival data with selpercatinib in RET-positive disease and its implications for adjuvant therapy.
• CROWN 7yr Update: seven-year progression-free survival results with lorlatinib in ALK-positive non-small cell lung cancer and the associated side effects.
• CHRYSALIS-2: exciting findings regarding amivantamab for atypical EGFR mutations and its potential to become the new standard of care.
• HARMONi-6: dual-headed drug ivonescimab combined with chemotherapy in metastatic squamous cell lung cancer and its intriguing results.

We also touched on the importance of molecular testing for all patients, regardless of stage or histology, and highlighted the latest updates on tarlatamab in small cell lung cancer.

 

Listen us on:
Spotify: https://open.spotify.com/show/31BXhY9FM4gPWG10WgE11o 

Follow us on social media:

• X/Twitter: https://twitter.com/oncbrothers 
• ⁠Instagram: https://www.instagram.com/oncbrothers 
• Website: https://oncbrothers.com/ 

 

Tune in for an insightful discussion that aims to keep our oncology community informed and engaged with the latest research and treatment options!

Don't forget to like, subscribe, and check out our other episodes for more insights on oncology treatments, conference highlights, and FDA approvals.

#ASCO2026, #LungCancer, #ALKPositive, #RETPositive, #OncologyBrothers