Managing Toxicities of Colorectal Cancer Drugs / Systemic Therapy – Dr. Rona Yaeger

Welcome to the third episode of our three-part series on colorectal cancer! In this episode of the Oncology Brothers we are joined by Dr. Rona Yaeger, a medical oncologist from the Memorial Sloan Kettering Cancer Center. Together, we dived into the management of common side effects associated with systemic treatments for colorectal cancer.

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Episode Highlights:
• Overview of 5-FU and capecitabine, including the importance of DPYD mutation testing and side effects like cytopenia, mucositis, and cardiac toxicity.
• Discussion on the use of 5-FU bolus in both metastatic and adjuvant settings.
• Insights into managing oxaliplatin-induced neuropathy and the potential benefits of oral cryotherapy.
• Clinical pearls for irinotecan, including the management of diarrhea and cholinergic effects.
• Considerations for using Bevacizumab, including risks of hypertension, proteinuria, and blood clots.
• Tips for managing side effects of anti-EGFR agents like Cetuximab and Panitumumab, including rash and infusion reactions.
• An overview of oral agents such as encorafenib, TAS-102, and Regorafenib, with a focus on dosing strategies and side effect management.

Join us as we explore these critical topics and provide valuable insights for healthcare professionals managing colorectal cancer treatments. Don't forget to subscribe for more episodes!

#ColorectalCancer, #SideEffectManagement, #DPYDtesting, #ChemotherapyToxicity, #SupportiveCare