Oncology Brothers: Practice-Changing Cancer Discussions
The Oncology Brothers Podcast, led by Drs. Rahul and Rohit Gosain, is dedicated to bridging the gap between academic cancer centers and community oncology in the ever-evolving field of hematology & oncology. With a mission to disseminate crucial information to the medical community, this oncology podcast is not for medical advice but rather serves as a beacon for physicians, nurses, trainees, and advanced practice providers (APPs) involved in the care of cancer patients. Drs. Rahul and Rohit Gosain, both esteemed oncologists, bring a wealth of experience and expertise from their general community practice to these discussions. Through short and engaging interviews with world-renowned researchers, clinicians, hematologists, and oncologists, they present practice-changing data in a concise, bite-sized format. Get the latest FDA approvals news, oncology conference highlights, and treatment algorithms in 25 minutes or less. Conversations center around common cancers you see in your clinic like breast cancer, prostate cancer, kidney cancer, bladder cancer, lung cancer, and GI cancers. With new indications and approvals, we talk about how to incorporate this data in your day to day clinical practice. Each episode includes visual presentations so you can follow along within the podcast players and on YouTube @oncbrothers. These visual tools and algorithms will provide an outline on what is covered in each episode. Immediately apply the latest insights and advancements in your daily practice, ensuring the delivery of optimal cancer care to patients within your local communities. If you want to navigate the complexities of your hematology & oncology practice and stay current, the Oncology Brothers Podcast offers invaluable insights and practical takeaways to enhance your professional journey and improve patient outcomes. For more information, please visit: www.oncbrothers.com, and connect with us on Twitter/X/Instagram/TikTok: @oncbrothers, or email us at info@oncbrothers.com
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Episodes
Tuesday Oct 22, 2024
Tuesday Oct 22, 2024
In this episode of the Oncology Brothers podcast, hosts Drs. Rahul and Rohit Gosain dive into the recent FDA approval of tarlatamab, a groundbreaking bispecific antibody for patients with extensive stage small cell lung cancer. Joined by Dr. Misty Shields from Indiana University, they explore the DeLLphi-301 study design, the efficacy of tarlatamab, and the operational challenges associated with its use.
Key topics discussed include:• The study's primary endpoint of objective response rate and its implications for patient care.• The unique mechanism of action of tarlatamab targeting DLL3 and CD3 T cells.• The importance of monitoring for side effects such as cytokine release syndrome (CRS) and immune cell-associated neurotoxicity syndrome (ICANS).• Strategies for community oncologists to effectively manage patients receiving this new treatment.
Dr. Shields also highlights the significance of patient advocacy and the role of organizations like Longevity Small Cell Smashers in supporting those affected by small cell lung cancer.
Tune in for an insightful discussion that sheds light on the future of treatment options for small cell lung cancer and the collaborative efforts needed to ensure patient safety and care.
Don't forget to like, subscribe, and hit the notification bell for more updates on the latest in oncology!
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Sunday Oct 20, 2024
Sunday Oct 20, 2024
Welcome to another episode of the Oncology Brothers podcast! In this episode, hosts Drs. Rahul and Rohit Gosain dive into the recent approval of Durvalumab in the perioperative settings for non-small cell lung cancer, based on the AEGEAN trial.
Join us as we welcome Dr. Sandip Patel, a medical oncologist from UCSD, and Dr. Mara Antonoff, a thoracic surgeon from MD Anderson, to discuss the implications of this new treatment option. We explore the study design of the AEGEAN trial, its differences from other trials like Keynote 671, and the importance of a multidisciplinary approach in managing lung cancer patients.
Key topics include: • Overview of the AGEAN trial and its findings • The significance of neoadjuvant and adjuvant therapies • The role of surgical evaluation and molecular profiling • Insights on patient selection and treatment strategies
As we shift towards more perioperative and postoperative treatments, understanding the nuances of these approaches is crucial for optimizing patient outcomes. Tune in for valuable insights and discussions that can help shape your practice!
Don't forget to like, subscribe, and hit the notification bell for more episodes on recent approvals and practice-changing data in oncology! #OncologyBrothers #LungCancer #Dervalumab #AEGEANTrial #MultidisciplinaryCare #MedicalOncology #ThoracicSurgery
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Thursday Oct 17, 2024
Thursday Oct 17, 2024
Welcome to the Oncology Brothers podcast! In this episode, hosts Drs. Rahul and Rohit Gosain are joined by Dr. Stephen Liu, Associate Professor and Director of Thoracic Oncology at the Georgetown Lombardi Comprehensive Cancer Center. Together, they dive into the latest findings from ESMO 2024, focusing on key studies in lung cancer that every community oncologist should be aware of.
Episode Highlights:• LAURA Trial: Discussing the role of osimertinib in locally advanced unresectable EGFR-mutant lung cancer post-chemoradiation and its impact on CNS progression-free survival.• MARIPOSA and MARIPOSA-2 Studies: Exploring the importance of amivantamab in metastatic non-small cell lung cancer, including insights on resistance patterns and treatment sequencing.• ADRIATIC Study: Analyzing the use of durvalumab as consolidation therapy in limited-stage small cell lung cancer and its implications for practice, including updates on prophylactic cranial irradiation (PCI).
Join us as we unpack these pivotal studies that are shaping the future of lung cancer treatment. Don't forget to check out our highlights on GI, GU, and breast cancer from ESMO 2024!
Subscribe for more insights and updates in oncology!
Website: http://www.oncbrothers.com/
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Contact us at info@oncbrothers.com
Tuesday Oct 15, 2024
Tuesday Oct 15, 2024
In this episode of the Oncology Brothers Podcast, hosts Drs. Rohit and Rahul Gosain welcome Dr. Shernan Holtan from Roswell Park Comprehensive Cancer Center to discuss the recent approval of Axatilimab, a novel monoclonal antibody for the treatment of chronic graft-versus-host disease (GVHD).
Join us as we explore the differences between acute and chronic GVHD, the challenges faced by community oncologists in managing this condition, and the exciting results from the AGAVE-201 study that led to Axatilimab's FDA approval. Dr. Holtan shares insights on the drug's mechanism of action, its dosing regimen, and the importance of patient-reported outcomes in assessing treatment efficacy.
We also delve into the safety profile of Axatilimab, discussing potential side effects, infusion reactions, and the significance of partnering with tertiary care centers for optimal patient management.
Whether you're a healthcare professional or simply interested in the latest advancements in oncology, this episode provides valuable information on managing chronic GVHD and improving patient quality of life.
Don't forget to like, subscribe, and check out our other episodes for more discussions on recent approvals and the current standard of care for various malignancies!#OncologyBrothers #GVHD #Axatilimab #ChronicGVHD #CancerCare #Podcast
Website: http://www.oncbrothers.com/
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Contact us at info@oncbrothers.com
Sunday Oct 13, 2024
Sunday Oct 13, 2024
In this episode of the Oncology Brothers podcast, hosts Drs. Rahul and Rohit Gosain are joined by Dr. Mikkael Sekeres, Professor of Medicine and Chief of the Division of Hematology at the University of Miami. Together, they explore the complex landscape of acute myeloid leukemia (AML), discussing the latest advancements in diagnosis, treatment options, and risk stratification.
Key topics included:
• The importance of molecular testing in AML diagnosis and treatment planning
• The role of intensive induction chemotherapy and the classic 7+3 regimen
• New oral therapies, including FLT3 inhibitors and hypomethylating agents combined with venetoclax
• Strategies for managing elderly or frail patients who are ineligible for intensive chemotherapy
• The significance of measurable residual disease (MRD) in treatment decisions and transplant eligibility
• Insights into managing side effects and complications associated with AML treatments
Join us for an informative discussion that sheds light on the evolving treatment landscape of AML and the importance of personalized care in oncology. Don't forget to check out our other episodes on hematological malignancies, and we look forward to seeing you at ASH 2024!
Subscribe to our channel for more insights and updates in the world of oncology!
Website: http://www.oncbrothers.com/
X/Twitter: https://twitter.com/oncbrothers
Contact us at info@oncbrothers.com
Thursday Oct 10, 2024
Thursday Oct 10, 2024
Join us in this exciting episode of the Oncology Brothers podcast as we dive into the highlights from ESMO 2024, focusing on gastrointestinal malignancies. Hosts Drs. Rohit and Rahul Gosain are joined by Dr. Kristen Ciombor, a GI medical oncologist from Vanderbilt University, to discuss four key studies that have significant implications for clinical practice.
In this episode, we covered:• LEAP-012 Study: An update on HCC treatment with Lenvatinib and Pembrolizumab combined with TACE, exploring the promising progression-free survival (PFS) data and the need for mature overall survival (OS) results.• Keynote-811: The current standard of care for HER2-positive gastroesophageal junction and gastric adenocarcinoma, highlighting improved OS with Pembrolizumab, chemotherapy, and Trastuzumab.• POD1UM-303 Trial: A groundbreaking study in metastatic anal cancer that shows significant OS improvement with the addition of the PD-1 inhibitor Retifanlimab to chemotherapy.• NICHE-2 Study: A remarkable update on MSI-high patients, showcasing a 100% three-year disease-free survival rate with neoadjuvant immunotherapy.
Tune in for an insightful discussion that will keep you updated on the latest advancements in GI oncology! Don't forget to like, subscribe, and hit the notification bell for more conference highlights and oncology discussions.#OncologyBrothers #ESMO24 #GIMalignancies #CancerResearch #Podcast
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Thursday Oct 03, 2024
Thursday Oct 03, 2024
Join us as we dive into four pivotal studies:
1. NIAGARA Trial: Explore the groundbreaking findings on the combination of chemotherapy and immunotherapy in the perioperative setting for patients with resectable muscle-invasive bladder cancer, which may now set a new standard of care.
2. TiNiVO-2 Study: Learn why re-challenging patients with immunotherapy after progression on prior immunotherapy is not recommended, and what alternative treatments may be more effective.
3. PEACE-3 Study: Discover the implications of combining enzalutamide with radium-223 in metastatic castration-resistant prostate cancer and its impact on progression-free survival.
4. CONTACT-02 Study: Understand the results comparing cabozantinib with atezolizumab against a second novel hormonal therapy, and what this means for overall survival in specific patient populations.
Tune in for an insightful discussion that highlights the latest advancements in GU cancer treatment and their potential impact on clinical practice. Don't forget to check out our other episodes covering breast cancer, lung cancer, and GI malignancies from ESMO 2024!
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Thursday Sep 26, 2024
Thursday Sep 26, 2024
Welcome to the Oncology Brothers podcast! In this episode, hosts Drs. Rahul and Rohit Gosain are joined by Dr. Paolo Tarantino from the Dana-Farber Cancer Institute to discuss the latest highlights from ESMO 2024, focusing on groundbreaking studies in breast cancer.
Join us as we dive into three key abstracts that have the potential to impact current clinical practice:
1. NATALEE Trial: Discover how the addition of ribociclib to endocrine therapy has shown improved invasive disease-free survival in early-stage breast cancer, including node-negative patients. Ribociclib was recently approved for this indication, and we discuss its implications for patient care.
2. Keynote 522 Update: We explore the updated results demonstrating an overall survival benefit with the perioperative use of pembrolizumab in combination with neoadjuvant chemotherapy for early-stage triple-negative breast cancer. This regimen continues to be a standard of care.
3. DESTINY Breast-12: Learn about the promising intracranial activity of trastuzumab durextecan in HER2-positive breast cancer patients with brain metastases, showcasing its potential to change treatment trajectories.
Tune in for an insightful discussion that highlights the evolving landscape of breast cancer treatment and offers hope for patients. Don't forget to check out our other episodes covering GI, lung, and GU cancer conference highlights!
Subscribe for more updates and insights from the Oncology Brothers!
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Contact us at info@oncbrothers.com
Thursday Sep 19, 2024
Thursday Sep 19, 2024
Welcome to the Oncology Brothers podcast! In this episode, hosts Drs. Rahul and Rohit Gosain are joined by Dr. Gilberto Lopes, Chief of Medical Oncology at the Sylvester Comprehensive Cancer Center, to discuss the highlights from the World Conference on Lung Cancer 2024.
Join us as we dive into four key studies that could reshape our understanding and approach to lung cancer treatment:
1. Checkmate 816 vs. Checkmate 77T: An exploratory analysis of neoadjuvant chemoimmunotherapy and the ongoing debate about the benefits of post-operative immunotherapy.
2. SKIPPirr Study: Discover how prophylactic strategies can reduce infusion-related reactions with amivantamab.
3. HARMONi-2: A look at a novel PD-1 and VEGF inhibitor compared to Pembrolizumab in metastatic non-small cell lung cancer.
4. TROPION-Lung01: Insights into the performance of the antibody-drug conjugate Dato-DXd against docetaxel, particularly in non-squamous histology.
Tune in for an informative discussion that highlights the latest advancements in lung cancer research and treatment strategies.
Don't forget to like, subscribe, and check out our other episodes for more insights into the current standard of care in oncology!
#OncologyBrothers #LungCancer #WCLC2024 #CancerResearch #MedicalOncology
Website: http://www.oncbrothers.com/
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Thursday Aug 29, 2024
Thursday Aug 29, 2024
Join the Oncology Brothers, Drs. Rahul and Rohit Gosain, as they dive into the world of Chronic Myeloid Leukemia (CML) with world-renowned hematologist Dr. Jorge Cortes from the Georgia Cancer Center. In this episode, they discuss the current standard of care treatment options for CML, including risk stratification, monitoring, treatment algorithms, and side effects of first, second, and third-generation TKIs.
Dr. Cortes provides valuable insights on when to consider treatment holidays, switching therapies, and the potential benefits of upcoming treatments like asciminib. The discussion also covers the importance of deep molecular responses, the role of bone marrow biopsies, and the decision-making process for patients in accelerated phase CML.
Tune in to gain a comprehensive understanding of managing CML patients in the community setting and stay updated on the latest advancements in hematology and oncology. Don't miss out on this informative episode with the Oncology Brothers podcast!
Website: http://www.oncbrothers.com/
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Contact us at info@oncbrothers.com