Oncology Brothers: Practice-Changing Cancer Discussions
The Oncology Brothers Podcast, led by Drs. Rahul and Rohit Gosain, is dedicated to bridging the gap between academic cancer centers and community oncology in the ever-evolving field of hematology & oncology. With a mission to disseminate crucial information to the medical community, this oncology podcast is not for medical advice but rather serves as a beacon for physicians, nurses, trainees, and advanced practice providers (APPs) involved in the care of cancer patients.
Drs. Rahul and Rohit Gosain, both esteemed oncologists, bring a wealth of experience and expertise from their general community practice to these discussions. Through short and engaging interviews with world-renowned researchers, clinicians, hematologists, and oncologists, they present practice-changing data in a concise, bite-sized format.
Get the latest FDA approvals news, oncology conference highlights, and treatment algorithms in 25 minutes or less. Conversations center around common cancers you see in your clinic like breast cancer, prostate cancer, kidney cancer, bladder cancer, lung cancer, and GI cancers. With new indications and approvals, we talk about how to incorporate this data in your day to day clinical practice.
Each episode includes visual presentations so you can follow along within the podcast players and on YouTube @oncbrothers. These visual tools and algorithms will provide an outline on what is covered in each episode. Immediately apply the latest insights and advancements in your daily practice, ensuring the delivery of optimal cancer care to patients within your local communities.
If you want to navigate the complexities of your hematology & oncology practice and stay current, the Oncology Brothers Podcast offers invaluable insights and practical takeaways to enhance your professional journey and improve patient outcomes. For more information, please visit: www.oncbrothers.com, and connect with us on Twitter/X/Instagram/TikTok: @oncbrothers, or email us at info@oncbrothers.com
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Episodes
Monday Aug 04, 2025
Monday Aug 04, 2025
In this episode of the Oncology Brothers podcast, Drs. Rahul and Rohit Gosain dived deep into the world of myeloproliferative neoplasms (MPNs), focusing specifically on polycythemia vera (PV) and essential thrombocythemia (ET). They are joined by Dr. Andrew Kuykendall, a hematologist from Moffitt Cancer Center, who shared his expertise on the latest treatment paradigms and risk stratification strategies for these conditions.
Key topics discussed included:• The importance of ruling out secondary causes of erythrocytosis in PV patients.• The role of JAK2 mutation testing and EPO levels in diagnosis of PV.• Treatment options for PV, including phlebotomy, hydroxyurea, and interferon, as well as the emerging role of ruxolitinib.• Risk stratification in ET and the significance of driver mutations like JAK2, CALR, and MPL.• The management of acquired von Willebrand disease in patients with high platelet counts.• Insights from Dr. Kuykendall's recent ASCO plenary presentation on the VERIFY Study and the potential of resveratide in PV treatment.
Join us for an informative discussion that highlights the evolving landscape of MPN management and the importance of individualized treatment plans.
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Don't forget to check out our other hematology episodes for more insights into challenging cases and treatment algorithms!
Thursday Jul 31, 2025
Thursday Jul 31, 2025
Welcome to the Oncology Brothers podcast! In this episode, hosts Drs. Rahul and Rohit Gosain, practicing community oncologists, share their key takeaways from a session on NTRK Fusion Positive Solid Malignancies, they moderated during a satellite event at ASCO 2025 in partnership with Medscape Global Oncology.
Join us as we discuss:• The prevalence of NTRK fusions in various cancers and why community oncologists should be aware of them.• The importance of comprehensive next-generation sequencing (NGS) for detecting these fusions across diverse histologies.• Available treatment options, including first-generation NTRK inhibitors like larotrectinib and entrectinib, and their efficacy in improving overall and progression-free survival.• Insights into the CNS activity of these treatments and the common side effects patients may experience.• Special considerations for pediatric patients, including formulation challenges and the potential for re-challenging with NTRK inhibitors.
Don't forget to check out the full accredited enduring program by Medscape Global Oncology linked below, and earn your CME credit.
https://www.medscape.org/viewarticle/1002679?src=acdmpart_onc-brothers_1002679
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#entrectinib #larotrectinib #repotrectinib
Monday Jul 28, 2025
Monday Jul 28, 2025
In this episode of the Oncology Brothers podcast, Drs. Rahul and Rohit Gosain dive into the complexities of relapsed refractory Acute Myeloid Leukemia (AML) with FLT3 mutations. Joined by leukemia specialists Dr. Uma Borate from the Ohio State University and Dr. Naval Daver from the MD Anderson Cancer Center, the discussion focused on real-life cases and the current standard of care for patients with FLT3-positive AML.
Key topics included:• The importance of retesting for FLT3 mutations at the time of relapse• Treatment paradigms for fit vs. unfit patients• The role of Gilteritinib and combination therapies in relapsed settings• Management of side effects, including cytopenias and differentiation syndrome• Insights into the use of hypomethylating agents and the potential of oral therapies
Whether you're a healthcare professional or someone interested in the latest advancements in cancer care, this episode provides valuable insights into the management of challenging AML cases.
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Don't forget to subscribe for more discussions on the latest in oncology!
Thursday Jul 24, 2025
Thursday Jul 24, 2025
In this episode of The Oncology Brothers, Drs. Rahul and Rohit Gosain are joined by Dr. Anand Patel, a hematologist and Medical Director of Inpatient Leukemia Service at the University of Chicago. Together, they delved into the complexities of acute myeloid leukemia (AML), one of the most aggressive cancers encountered in clinical practice.
Episode Highlights:• Understanding the current standard of care for AML, including diagnosis and risk stratification.• The importance of molecular profiling and how it influences treatment decisions.• A detailed discussion on induction chemotherapy options, including the classic 7+3 regimen and CPX351 for therapy-related AML.• Insights into the use of hypomethylating agents combined with venetoclax for patients unfit for intensive chemotherapy.• The role of targeted therapies in both upfront treatment and relapsed/refractory settings.• Key considerations for managing side effects, including cytopenias and infections.
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YouTube: https://youtu.be/gbgRbrjHxmQ
Join us as we bridge the gap between academic research and community practice, providing valuable insights for healthcare professionals treating AML patients.
Don't forget to like, subscribe, and check out our other episodes for more discussions on challenging cases and treatment algorithms!
Monday Jul 21, 2025
Monday Jul 21, 2025
Welcome to this episode of The Oncology Brothers! Drs. Rahul and Rohit Gosain dived into the complexities of relapsed refractory diffuse large B-cell lymphoma (DLBCL) with their new series focused on challenging real-life cases.
In this episode, we are joined by esteemed guests Dr. Carla Casulo from Wilmot Cancer Center and Dr. Tara Graff from Mission Cancer and Blood Center. Together, we explored the current standard of care, including R-CHOP and the role of bi-specific antibodies like epcoritamab and glofitimab.
Key topics covered included:• When to use bi-specific antibodies and how to manage side effects• The importance of MRD monitoring in treatment decisions• Insights on patient management in community oncology settings• The evolving landscape of treatment options for DLBCL, including CAR-T therapy and clinical trials
We also discuss practical considerations for community oncologists, including the management of cytokine release syndrome (CRS) and the role of immunoglobulin therapy in patients with low IgG levels.Whether you're a healthcare professional or someone interested in the latest advancements in oncology, this episode is packed with valuable insights and expert opinions.
YouTube: https://youtu.be/05ieIyAIx_8
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Don't forget to like, subscribe, and share your thoughts in the comments! Let us know if there are specific scenarios you'd like us to cover in future episodes.
Thursday Jul 17, 2025
Thursday Jul 17, 2025
Welcome to the Oncology Brothers podcast! In this episode, Drs. Rohit and Rahul Gosain dive deep into the world of diffuse large B-cell lymphoma (DLBCL), one of the most aggressive yet potentially curable lymphomas. We are joined by Dr. John Leonard, a renowned lymphoma expert from NYU Langone Cancer Center, who shares his insights on the latest data and evolving treatment landscape for DLBCL.
Episode Highlights:• Understanding the initial workup for DLBCL, including the role of PET-CT and bone marrow biopsies.• The use of RCHOP and the emerging Pola-R-CHP regimen in Stage 1 and Stage 2 settings.• Discussion on the treatment options for Stage 3 and Stage 4 disease, including the impact of polatuzumab.• Insights into managing relapsed/refractory disease and the role of CAR-T therapy.• The potential shift towards outpatient CAR-T treatments and the nuances between different CAR-T options.• Exploring bispecific antibodies and their applications in treatment sequencing.
YouTube: https://youtu.be/raGkPnUs9XM
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Join us as we unpack the complexities of DLBCL treatment and share valuable clinical pearls for community settings. Don't forget to subscribe for more episodes on challenging cases and the latest in oncology!
Thursday Jul 10, 2025
Thursday Jul 10, 2025
In this episode of the Oncology Brothers podcast, Drs. Rahul and Rohit Gosain are joined by Dr. Deepa Rangachari, a thoracic medical oncologist and fellowship program director at Beth Israel Deaconess Medical Center. Together, they dived deep into the treatment algorithms for early-stage non-small cell lung cancer (NSCLC) with a focus on curative intent.
Key topics discussed include:• The importance of staging and lymph node evaluation in treatment planning.• The role of neoadjuvant chemoimmunotherapy and the impact of recent trial data, including the CHECKMATE 816 trial.• The significance of actionable mutations and the use of targeted therapies like Osimertinib and Alectinib.• The evolving role of ctDNA in treatment decisions and monitoring.• Insights into the management of side effects associated with Osimertinib and Alectinib.• The standard of care for unresectable stage 3 NSCLC, including concurrent chemoradiation and the use of Durvalumab.
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Join us for an informative discussion that highlights the latest advancements in lung cancer treatment and the importance of personalized care. Don't forget to check out our other episodes in the lung cancer treatment algorithm series!
Friday Jul 04, 2025
Friday Jul 04, 2025
Welcome to another episode of the Oncology Brothers podcast! In this episode, Drs. Rahul and Rohit Gosain, both practicing community oncologists, are joined by Dr. Tian Zhang from UT Southwestern to discuss key highlights from the ASCO 2025 annual meeting, focusing on genitourinary (GU) malignancies.
Episode Highlights:• KEYNOTE-564: discussed 5 years OS data, reinforcing the role of adjuvant pembrolizumab in renal cell carcinoma• AMPLITUDE: combination of PARP inhibitor niraparib with abiraterone improved progression-free survival in patients with homologous recombination repair mutations in metastatic hormone-sensitive prostate cancer• ARANOTE: positive quality of life impact when using darolutamide in metastatic hormone-sensitive prostate cancer, which is also FDA approved now• NIAGARA: the prognostic value of ctDNA in muscle-invasive bladder cancer, emphasizing its implications for treatment strategies
YouTube: https://youtu.be/Rt8HQpdyVY0
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Join us as we break down these important studies and their potential to change clinical practice in oncology. Don't forget to check out our other episodes for more insights into cancer care!
Friday Jun 27, 2025
Friday Jun 27, 2025
Welcome to another episode of the Oncology Brothers podcast! In this episode, Drs. Rahul and Rohit Gosain are joined by Dr. Ross Camidge, a leading thoracic medical oncologist from the University of Colorado, to discuss the recent approval of telisotuzumab-vedotin (Teliso-V) for metastatic non-small cell lung cancer (NSCLC) with C-met overexpression, based on the LUMINOSITY trial.
Join us as we explore:• The mechanism of action of telisotuzumab and its role as an antibody-drug conjugate.• The prevalence of C-met overexpression in NSCLC and its implications for testing and treatment.• Key findings from the Luminosity trial, including response rates and study design.• The importance of C-met testing in clinical practice.• Management of side effects associated with telisotuzumab, particularly peripheral neuropathy.
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This episode is packed with valuable insights for oncologists and healthcare professionals navigating the evolving landscape of lung cancer treatment. Don't miss out on this informative discussion!
Friday Jun 20, 2025
Friday Jun 20, 2025
Welcome to the Oncology Brothers podcast! In this episode, Drs. Rahul and Rohit Gosain are joined by Dr. Erika Hamilton from the Sarah Cannon Research Institute to discuss the latest breakthroughs in breast cancer presented at the ASCO 2025 annual meeting.
We dived into five key abstracts that could change the landscape of breast cancer treatment:1. INAVO120: observed overall survival data with the combination of inavolisib, with palbociclib and fulvestrant for patients with PIK3CA mutated hormone receptor-positive, HER2-negative advanced breast cancer.2. SERENA-6: camizestrant use in patients with emerging ESR1 mutations using ctDNA, showed significant improvement in progression-free survival.3. VERITAC-2: vepdegestrant showed superior progression-free survival compared to fulvestrant, particularly in ESR1 mutated patients.4. DESTINY-Breast09: significant improvement in progression-free survival with TDXd plus pertuzumab in frontline HER2-positive metastatic breast cancer, challenging the traditional CLEOPATRA regimen THP.5. ASCENT-04: promising results of sacituzumab combined with pembrolizumab in PD-L1 positive triple-negative breast cancer.
Join us for an insightful discussion on these practice changing/informing studies and their implications for clinical practice.
YouTube: https://youtu.be/5XvrOn2p0jc
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Don't forget to like, subscribe, and check out our other episodes for more updates on treatment algorithms, recent approvals, and conference highlights!